Neural correlates of global and specific cognitive deficits in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:201

Article

Jirsaraie, Robert J.¹  Sheffield, Julia M.²  Barch, Deanna M.^2,3 

[1] Univ Colorado, Dept Psychol, 1250 14th St, Denver, CO 80204 USA

[2] Washington Univ, Dept Psychol & Brain Sci, Box 1125,One Brookings Dr, St Louis, MO 63130 USA

[3] Washington Univ, Dept Psychiat, Box 1125,One Brookings Dr, St Louis, MO 63130 USA

关键词: Brain volume;    Structural MRI;    White matter;    Dorsolateral prefrontal cortex;    Hippocampus;    Cognitive deficits;   

DOI  :  10.1016/j.schres.2018.06.017

来源: Elsevier

【 摘 要 】

Cognitive deficits are a core feature of schizophrenia, but the neuralmechanisms that contribute to these characteristics are not fully understood. This study investigated whether volume of the dorsal lateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG), hippocampus, and white matter were associated with impairment in specific cognitive domains, including executive functioning, working memory, verbal memory, verbal fluency, processing speed, versus global functioning. Themulti-site data used in this studywas collected fromthe Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP), and consisted of 206 healthy controls and 247 individuals with either schizophrenia or schizoaffective disorder. The neuroimaging data was segmented based on the Destrieux atlas in FreeSurfer. Linear regression analyses revealed that global cognition, executive functioning, workingmemory, and processing speed were associated with all brain structures, except the DLPFC was only associated with executive fucntion. When controlling for the global cognitive deficit, executive function was trending significance with white matter, but continued to be associated with the DLPFC and IFG, as did the association between processing speed and the hippocampus. These findings suggest that volumes of the DLPFC, IFG, hippocampus, and white matter are associated with the global cognitive impairment seen in schizophrenia, but some brain structures may also be specifically related to domain-specific deficits (primarily executive function) over-and-beyond the global cognitive deficit. (C) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

Free