Neuropsychological profiles in individuals at clinical high risk for psychosis: Relationship to psychosis and intelligence

SCHIZOPHRENIA RESEARCH

卷:123

Article

Woodberry, Kristen A.^1,2,3,4  Seidman, Larry J.^1,4  Giuliano, Anthony J.^1,4  Verdi, Mary B.²  Cook, William L.²  McFarlane, William R.² 

[1] Beth Israel Deaconess Med Ctr, Dept Psychiat, Massachusetts Mental Hlth Ctr, Div Publ Psychiat, Boston, MA 02215 USA

[2] Maine Med Ctr, Ctr Psychiat Res, Portland, ME 04102 USA

[3] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[4] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA

关键词: Schizophrenia;    Prodrome;    Cognition;    Ultra high risk;    Neurocognitive functioning;    IQ;   

DOI  :  10.1016/j.schres.2010.06.021

来源: Elsevier

【 摘 要 】

Background: Characterizing neuropsychological (NP) functioning of individuals at clinical high risk (CHR) for psychosis may be useful for prediction of psychosis and understanding functional outcome. The degree to which NP impairments are associated with general cognitive ability and/or later emergence of full psychosis in CHR samples requires study with well-matched controls. Methods: We assessed NP functioning across eight cognitive domains in a sample of 73 CHR youth, 13 of whom developed psychotic-level symptoms after baseline assessment, and 34 healthy comparison (HC) subjects. Groups were matched on age, sex, ethnicity, handedness, subject and parent grade attainment, and median family income, and were comparable on WRAT-3 Reading, an estimate of premorbid IQ. Profile analysis was used to examine group differences and the role of IQ in profile shape. Results: The CHR sample demonstrated a significant difference in overall magnitude of NP impairment but only a small and nearly significant difference in profile shape, primarily due to a large impairment in olfactory identification. Individuals who subsequently developed psychotic-level symptoms demonstrated large impairments in verbal IQ verbal memory and olfactory identification comparable in magnitude to first episode samples. Conclusions: CHR status may be associated with moderate generalized cognitive impairments marked by some degree of selective impairment in olfaction and verbal memory. Impairments were greatest in those who later developed psychotic symptoms. Future study of olfaction in CHR samples may enhance early detection and specification of neurodevelopmental mechanisms of risk. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

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