Glutamatergic abnormalities in schizophrenia: A review of proton MRS findings

SCHIZOPHRENIA RESEARCH

卷:152

Review

Poels, Eline M. P.^1,2  Kegeles, Lawrence S.^1,2,3  Kantrowitz, Joshua T.^1,2  Javitt, Daniel C.^1,2  Lieberman, Jeffrey A.^1,2  Abi-Darghama, Anissa^1,2,3  Girgis, Ragy R.^1,2 

[1] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA

[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA

关键词: Schizophrenia;    Glutamate;    Glutamine;    Glx;    Magnetic Resonance Spectroscopy (MRS);    NMDA;   

DOI  :  10.1016/j.schres.2013.12.013

来源: Elsevier

【 摘 要 】

The last fifteen years have seen a great increase in our understanding of the role of glutamate in schizophrenia (SCZ). The glutamate hypothesis focuses on disturbances in brain glutamatergic pathways and impairment in signaling at glutamate receptors. Proton Magnetic Resonance Spectroscopy (H-1-MRS) is an MR-based technique that affords investigators the ability to study glutamate function by measuring in vivo glutamatergic indices in the brains of individuals with SCZ. H-1-MRS studies have been performed comparing glutamatergic levels of individuals with SCZ and healthy control subjects or studying the effect of antipsychotic medications on glutamatergic levels. In this article we summarize the results of these studies by brain region. We will review the contribution of H-1-MRS studies to our knowledge about glutamatergic abnormalities in the brains of individuals with SCZ and discuss the implications for future research and clinical care. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free