Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

SCHIZOPHRENIA RESEARCH

卷:202

Article

Rubin, Leah H.^1,2,3  Li, Siyi⁴  Yao, Li⁴  Keedy, Sarah K.⁵  Reilly, James L.⁶  Hill, Scot K.⁷  Bishop, Jeffrey R.^8,9  Carter, C. Sue¹⁰  Pournajafi-Nazarloo, Hossein¹⁰  Drogos, Lauren L.^11,12  Gershon, Elliot⁵  Pearlson, Godfrey D.^13,14,15  Tamminga, Carol A.¹⁶  Clementz, Brett A.¹⁷  Keshavan, Matcheri S.^18,19  Lui, Su⁴  Sweeney, John A.^4,16,20 

[1] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[2] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[4] Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Xiang, Chengdu 610041, Sichuan, Peoples R China

[5] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA

[6] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[7] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL USA

[8] Univ Minnesota, Dept Pharm, Minneapolis, MN USA

[9] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[10] Kinsey Inst, Bloomington, IN USA

[11] Univ Calgary, Hotchkiss Brain Inst, Dept Physiol, Calgary, AB, Canada

[12] Univ Calgary, Hotchkiss Brain Inst, Dept Pharmacol, Calgary, AB, Canada

[13] Yale Univ, Dept Psychiat, Hartford, CT USA

[14] Yale Univ, Dept Neurobiol, Hartford, CT USA

[15] Olin Neuropsychiat Res Ctr, Hartford, CT USA

[16] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX USA

[17] Univ Georgia, Dept Psychol, Athens, GA 30602 USA

[18] Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02215 USA

[19] Harvard Med Sch, Boston, MA USA

[20] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45221 USA

关键词: Sex differences;    Resting state;    Schizophrenia;    Oxytocin;    Vasopressin;    Functional MRI;   

DOI  :  10.1016/j.schres.2018.07.003

来源: Elsevier

【 摘 要 】

Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Methods: OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site. Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity. Results: In female patients, lower OT levels were associated with lower ALFF in frontal and cerebellar cortices (p's <0.05) and in female controls AVP levels were inversely associated with ALFF in the frontal cortex (p = 0.01). In male patients, lower OT levels were associated with lower ALFF in the posterior cingulate and lower AVP levels were associated with lower ALIT in frontal cortex (p's < 0.05). In male controls, lower OT levels were associated with lower ALFF in frontal cortex and higher ALFF in the thalamus (p's < 0.05). There were some inverse ALFF-behavior associations in patients. Conclusions: Alterations in peripheral hormone levels are associated with resting brain physiology in a sex-dependent manner in schizophrenia. These effects may contribute to sex differences in psychiatric symptom severity and course of illness in schizophrenia. (C) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

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