Abnormal white matter integrity in antipsychotic-naive first-episode psychosis patients assessed by a DTI principal component analysis

SCHIZOPHRENIA RESEARCH

卷:162

Article

Alvarado-Alanis, Patricia¹  Leon-Ortiz, Pablo^1,2  Reyes-Madrigal, Francisco¹  Favila, Rafael³  Rodriguez-Mayoral, Oscar^4,5  Nicolini, Humberto⁶  Azcarraga, Mariana⁷  Graff-Guerrero, Ariel^8,9  Rowland, Laura M.^10,11  de la Fuente-Sandoval, Camilo^1,7 

[1] Inst Nacl Neurol & Neurocirug, Lab Expt Psychiat, Mexico City 14269, DF, Mexico

[2] Inst Nacl Neurol & Neurocirug, Dept Educ, Mexico City 14269, DF, Mexico

[3] GE Healthcare, MR Adv Applicat, Mexico City, DF, Mexico

[4] Hosp Fray Bernardino Alvarez, Early Psychosis Intervent Dept, Mexico City, DF, Mexico

[5] Inst Nacl Cancerol, Palliat Care Unit, Mexico City, DF, Mexico

[6] Inst Nacl Med Genom, Mexico City, DF, Mexico

[7] Inst Nacl Neurol & Neurocirug, Neuropsychiat Dept, Mexico City 14269, DF, Mexico

[8] Univ Toronto, Multimodal Neuroimaging Schizophrenia Grp, Res Imaging Ctr, Toronto, ON M5S 1A1, Canada

[9] Univ Toronto, Geriatr Mental Hlth, Ctr Addict & Mental Hlth, Dept Psychiat, Toronto, ON M5S 1A1, Canada

[10] Univ Maryland Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD USA

[11] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

关键词: Diffusion tensor imaging;    First-episode psychosis;    Schizophrenia;    Fractional anisotropy;    TBSS;    Principal component analysis;   

DOI  :  10.1016/j.schres.2015.01.019

来源: Elsevier

【 摘 要 】

Introduction: Diffusion tensor imaging (DTI) studies in patients with schizophrenia have shown abnormalities in the microstructure of white matter tracts. Specifically, reduced fractional anisotropy (FA) has been described across multiple white matter tracts, in studies that have mainly included patients treated with antipsychotic medications. Objective: To compare FA in antipsychotic-naive patients experiencing a first episode of psychosis (FEP) to FA in healthy controls to demonstrate that the variance of FA can be grouped, in a coincidental manner, in four predetermined factors in accordance with a theoretical partition of the white matter tracts, using a principal components analysis (PCA). Methods: Thirty-five antipsychotic-naive FEP patients and 35 age-and gender-matched healthy controls underwent DTI at 3 T. Analysis was performed using a tract-based spatial statistics (TBSS) method and exploratory PCA. Results: DTI analysis showed extensive FA reduction in white matter tracts in FEP patients compared with the control group. The PCA grouped the white matter tracts into four factors explaining 66% of the total variance. Comparison of the FA values within each factor highlighted the differences between FEP patients and controls. Discussion: Our study confirms extensive white matter tracts anomalies in patients with schizophrenia, more specifically, in drug-naive FEP patients. The results also indicate that a small number of white matter tracts share common FA anomalies that relate to deficit symptoms in FEP patients. Our study adds to a growing body of literature emphasizing the need for treatments targeting white matter function and structure in FEP patients. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free