Demographic and socioenvironmental predictors of premorbid marijuana use among patients with first-episode psychosis

SCHIZOPHRENIA RESEARCH

卷:197

Article

Pauselli, Luca¹  Birnbaum, Michael L.^2,3  Vazquez Jaime, Beatriz Paulina^4,5  Paolini, Enrico⁶  Kelley, Mary E.⁷  Broussard, Beth²  Compton, Michael T.¹ 

[1] Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USA

[2] Lenox Hill Hosp, Dept Psychiat, New York, NY 10021 USA

[3] Zucker Hillside Hosp, Glen Oaks, NY USA

[4] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Mexico City, DF, Mexico

[5] Hosp Psiquiatr Infantil Juan N Navarro, Mexico City, DF, Mexico

[6] Madonna del Soccorso Hosp, Dept Mental Hlth, San Benedetto Tronto, AP, Italy

[7] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

关键词: Cannabis;    First-episode psychosis;    Marijuana;    Psychosis;    Schizophrenia;   

DOI  :  10.1016/j.schres.2018.01.020

来源: Elsevier

【 摘 要 】

Objective: We identified, in subjects with first-episode psychosis, demographic and socioenvironmental predictors of three variables pertaining to premorbid marijuana use: age at initiation of marijuana use, trajectories of marijuana use in the five years prior to onset of psychosis, and the cumulative dose of marijuana intake in that same premorbid period. Methods: We enrolled 247 first-episode psychosis patients and collected data on lifetime marijuana/alcohol/tobacco use, age at onset of psychosis, diverse socioenvironmental variables, premorbid adjustment, past traumatic experiences, perceived neighborhood-level social disorder, and cannabis use experiences. Bivariate tests were used to examine associations between the three premorbid marijuana use variables and hypothesized predictors. Regression models determined which variables remained independently significantly associated. Results: Age at initiation of cigarette smoking was linked to earlier initiation, faster escalation, and higher cumulative dose of premorbid marijuana use. During childhood, poorer academic performance was predictive of an earlier age at initiation of marijuana use, while poorer sociability was related to more rapid escalation to daily use and a higher cumulative dose. As expected, experiencing euphoric effects was positively correlated with trajectories and cumulative dose, but having negative experiences was unrelated. Traumatic childhood/adolescent experiences were correlatedwith rapid escalation and amount of marijuana used, but not with age at initiation of marijuana use. Conclusion: These data expand the very limited literature on predictors of premorbid marijuana use in first episode psychosis. Given its association with earlier age at onset of psychosis, and poorer outcomes among first-episode patients, prevention and treatment efforts should be further developed. (c) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

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