The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis

SCHIZOPHRENIA RESEARCH

卷:172

Article

Moskow, Danielle M.^1,13  Addington, Jean²  Bearden, Carrie E.³  Cadenhead, Kristin S.⁴  Cornblatt, Barbara A.⁵  Heinssen, Robert⁶  Mathalon, Daniel H.⁷  McGlashan, Thomas H.⁸  Perkins, Diana O.⁹  Seidman, Larry J.¹⁰  Tsuang, Ming T.¹¹  Cannon, Tyrone D.¹²  Woods, Scott W.⁸  Walker, Elaine F.¹ 

[1] Emory Univ, 36 Eagle Row, Atlanta, GA 30322 USA

[2] Univ Calgary, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

[3] Univ Calif Los Angeles, 300 Med Plaza Suite 2265, Los Angeles, CA 90095 USA

[4] Univ Calif San Diego, 9500 Gilman Dr, La Jolla, CA 92093 USA

[5] Zucker Hillside Hosp, Glen Oaks, NY 11004 USA

[6] NIMH, 6001 Execut Blvd, Bethesda, MD 20893 USA

[7] Univ Calif San Francisco, 4150 Clement St, San Francisco, CA 94121 USA

[8] Yale Univ, 300 George St, New Haven, CT 06511 USA

[9] Univ N Carolina, 101 Manning Dr, Chapel Hill, NC 27514 USA

[10] Harvard Univ, 55 Friot St, Boston, MA 02114 USA

[11] Univ Calif San Diego, 9500 Gilman Dr, La Jolla, CA 92037 USA

[12] Yale Univ, 1 Prospect St, New Haven, CT 06511 USA

[13] Columbia Univ, Med Ctr, New York State Psychiat Inst, 1051 Riverside Dr, New York, NY 10032 USA

关键词: Schizophrenia;    Psychosis;    Puberty;    Stress;    Cortisol;    Clinical high risk;   

DOI  :  10.1016/j.schres.2016.02.002

来源: Elsevier

【 摘 要 】

Background: Prodromal syndromes often begin in adolescence - a period of neurodevelopmental changes and heightened stress sensitivity. Research has shown elevated stress and cortisol in individuals at clinical high risk (CHR) for psychosis. This cross-sectional study examined relations of age and pubertal status with cortisol and self-reported stress in healthy controls (HCs) and CHR adolescents. It was hypothesized that the relations of age and pubertal stage with cortisol and stress would be more pronounced in CHR youth. Methods: Participants were 93 HCs and 348 CHR adolescents from the North American Prodrome Longitudinal Study (NAPLS). At baseline, measures of stress (Daily Stress Inventory-DSI), Tanner stage (TS), and salivary cortisol were obtained. Results: ANCOVA revealed increased DSI scores with age for both groups, and higher DSI scores in CHR adolescents than HCs, with a more pronounced difference for females. Contrary to prediction, with age controlled, HCs showed greater TS-related DSI increases. Analysis of cortisol showed no significant interactions, but a main effect of age and a trend toward higher cortisol in the CHR group. Correlations of cortisol with TS were higher in HC than CHR group. Conclusions: Stress measures increased with age in HC and CHR adolescents, and DSI scores also increased with TS in HCs. The results do not support a more pronounced age or TS increase in stress measures in CHR adolescents, but instead suggest that stress indices tend to be elevated earlier in adolescence in the CHR group. Potential determinants of findings and future directions are discussed. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

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