Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness

SCHIZOPHRENIA RESEARCH

卷:222

Article

Matheson, Granville J.^1,2  Plaven-Sigray, Pontus^1,2  Louzolo, Anais³  Borg, Jacqueline^1,2  Farde, Lars^1,2,4  Petrovic, Predrag³  Cervenka, Simon^1,2 

[1] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden

[2] Stockholm Cty Council, SE-17176 Stockholm, Sweden

[3] Karolinska Inst, Dept Clin Neurosci, SE-17176 Stockholm, Sweden

[4] Karolinska Inst, AstraZeneca, IMED Biotech Unit, PET Sci Ctr,Precis Med & Genom, Stockholm, Sweden

关键词: Psychosis proneness;    Delusional ideation;    Dopamine D1;    Positron emission tomography;   

DOI  :  10.1016/j.schres.2020.06.001

来源: Elsevier

【 摘 要 】

The dopamine D1 receptor (D1R) is thought to play a role in psychosis and schizophrenia, however positron emission tomography studies comparing patients and controls have been inconsistent. To circumvent some of the limitations of clinical studies, such as antipsychotic exposure, an alternative approach is to examine subclinical psychotic symptoms within the general population, i.e. psychosis proneness traits. In this study, we investigated whether D1R availability is associated with delusional ideation in healthy controls, in four experiments, using [C-11]SCH23390 PET (n = 76) and psychometric questionnaires (n = 217). We performed exploratory analyses, direct self-replication, and confirmatory analyses using Bayesian statistical modelling. Collectively, we found strong evidence that there is little to no linear association between delusional ideation and D1R. If hypothesised changes in D1R in drug-naive psychosis patients can be confirmed, our results suggest that they may either occur at disease onset, or that they are associated with specific aspects of psychosis other than delusional ideation. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

Free