Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia: A preliminary study

SCHIZOPHRENIA RESEARCH

卷:135

Article

Dima, D.¹  Frangou, S.¹  Burge, L.²  Braeutigam, S.³  James, A. C.^2,4 

[1] Kings Coll London, Sect Neurobiol Psychosis, Dept Psychosis Studies, Inst Psychiat, London SE5 8AF, England

[2] Warneford Hosp, Highfield Adolescent Unit, Oxford OX3 7JX, England

[3] Warneford Hosp, Oxford Ctr Human Brain Act, Oxford OX3 7JX, England

[4] Univ Oxford, Dept Psychiat, Warneford Hosp, Oxford OX3 7JX, England

关键词: Dysconnection syndrome;    Dynamic causal modelling;    Experience dependent modulation;    Connectivity;    Error prediction;    Mismatch negativity;   

DOI  :  10.1016/j.schres.2011.12.024

来源: Elsevier

【 摘 要 】

Altered neuroplasticity is increasingly invoked as a mechanism underpinning dysconnectivity in schizophrenia. We used Dynamic Causal Modelling to compare connectivity during the magnetic auditory Mismatch Negativity (MMN), an index of error prediction, between schizophrenia patients and controls. Patients showed reduced intrinsic connectivity within the primary auditory cortex suggestive of impaired local neuronal adaptation and disrupted forward and backward extrinsic connectivity throughout the MMN network indicative of reduced higher order input in disambiguating activity in lower network nodes. Our study provides the first empirical description of the dysplastic changes underpinning dysconnectivity between primary sensory and higher order cortical areas in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free