Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

SCHIZOPHRENIA RESEARCH

卷:164

Article

Carrion, Ricardo E.^1,2,3  Cornblatt, Barbara A.^1,2,3,4  McLaughlin, Danielle¹  Chang, Jeremy¹  Auther, Andrea M.^1,3  Olsen, Ruth H.¹  Javitt, Daniel C.^5,6 

[1] North Shore Long Isl Jewish Hlth Syst NS LIJHS, Div Psychiat Res, Glen Oaks, NY USA

[2] North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY 11030 USA

[3] Hofstra North Shore LIJ Sch Med, Dept Psychiat, Hempstead, NY USA

[4] Hofstra North Shore LIJ Sch Med, Dept Mol Med, Hempstead, NY USA

[5] Columbia Univ Coll Phys & Surg, Div Expt Therapeut, New York, NY 10032 USA

[6] Nathan S Kline Inst Psychiat Res, Div Schizophrenia Res, Orangeburg, NY 10962 USA

关键词: Early intervention;    Social functioning;    Clinical high risk;    Mismatch negativity;    Reading;   

DOI  :  10.1016/j.schres.2015.01.030

来源: Elsevier

【 摘 要 】

Background: There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. Methods: The sample consisted of 34 CHR individuals and 33 healthy comparison subjects (CNTLs) from the Recognition and Prevention (RAP) Program at the Zucker Hillside Hospital in New York. At baseline, reading measures were collected, along with MMN to pitch, duration, and intensity deviants, and measures of neurocognition, and social and role (academic/work) functioning. Results: CHR subjects showed impairments in reading ability, neurocognition, and MMN generation, relative to CNTLs. Lower-amplitude MMN responses were correlated with worse reading ability, slower processing speed, and poorer social and role functioning. However, when entered into a simultaneous regression, only reduced responses to deviance in sound duration and volume predicted poor social and role functioning, respectively. Conclusions: Deficits in reading ability exist even prior to illness onset in schizophrenia and may represent a decline in performance from prior abilities. As in schizophrenia, deficits are related to impaired MMN generation, suggesting specific contributions of sensory-level impairment to neurocognitive processes related to social and role function. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free