The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders - A systematic review of magnetic resonance spectroscopy studies

SCHIZOPHRENIA RESEARCH

卷:249

Review

Reddy-Thootkur, Mounica¹  Kraguljac, Nina Vanessa¹  Lahti, Adrienne Carol^1,2 

[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, SC 501,1720 7th Ave S, Birmingham, AL 35294 USA

关键词: Psychosis;    Bipolar disorder;    Major depressive disorder;    Glutamate;    GABA;    MRS;    fMRI;    Multimodal neuroimaging;   

DOI  :  10.1016/j.schres.2020.02.001

来源: Elsevier

【 摘 要 】

Epidemiologic, genetic, and neurobiological studies suggest considerable overlap between schizophrenia and mood disorders. Importantly, both disorders are associated with a broad range of cognitive deficits as well as al-tered glutamatergic and GABAergic neurometabolism. We conducted a systematic review of magnetic resonance spectroscopy (MRS) studies investigating the relationship between glutamatergic and GABAergic neurometabolites and cognition in schizophrenia spectrum disorders and mood disorders. A literature search in Pubmed of studies published before April 15, 2019 was conducted and 37 studies were deemed eligible for sys-tematic review. We found that alterations in glutamatergic and GABAergic neurotransmission have been identi-fied relatively consistently in both schizophrenia and mood disorders. However, because of the vast heterogeneity of published studies in terms of illness stage, medication exposure, MRS acquisition parameters and data post-processing strategies, we still do not understand the relationship between those neurotransmitters and cognitive dysfunction in mental illness, which is a critical initial step for rational drug development. Our find-ings emphasize the need for coordinated multi-center studies that characterize cognitive function and its biolog-ical substrates in large and well-defined clinical populations, using harmonized imaging sequences and analytical methods with the goal to elucidate the underlying pathophysiological mechanisms and to inform future clinical trials. (c) 2020 Published by Elsevier B.V.

【 授权许可】

Free