Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder

SCHIZOPHRENIA RESEARCH

卷:150

Article

Ratnanather, J. Tilak^1,2,3  Poynton, Clare B.¹  Pisano, Dominic V.¹  Crocker, Britni¹  Postell, Elizabeth¹  Cebron, Shannon¹  Ceyhan, Elvan⁴  Honeycutt, Nancy A.⁵  Mahon, Pamela B.⁵  Barta, Patrick E.^1,2 

[1] Johns Hopkins Univ, Ctr Imaging Sci, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Inst Computat Med, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[4] Koc Univ, Dept Math, Istanbul, Turkey

[5] Johns Hopkins Univ, Dept Psychiat, Sch Med, Baltimore, MD 21205 USA

关键词: Laminar thickness;    Superior temporal gyrus;    Planum temporale;    Schizophrenia;    Bipolar disorder;    Laterality;   

DOI  :  10.1016/j.schres.2013.08.014

来源: Elsevier

【 摘 要 】

Structural abnormalities in temporal lobe, including the superior temporal gyrus (STG) and planum temporale (PT), have been reported in schizophrenia (SCZ) and bipolar disorder (BPD) patients. While most MRI studies have suggested gray matter volume and surface area reduction in temporal lobe regions, few have explored changes in laminar thickness in PT and STG in SCZ and BPD. ROI subvolumes of the STG from 94 subjects were used to yield gray matter volume, gray/white surface area and laminar thickness for STG and PT cortical regions. Morphometric analysis suggests that there may be gender and laterality effects on the size and shape of the PT in BPD (n = 36) and SCZ (n = 31) with reduced laterality in PT in subjects with SCZ but not in BPD. In addition, PT surface area was seen to be larger in males, and asymmetry in PT surface area was larger in BPD. Subjects with SCZ had reduced thickness and smaller asymmetry in PT volume. Thus, the PT probably plays a more sensitive role than the STG in structural abnormalities seen in SCZ. (C) 2013 Elsevier B. V. All rights reserved.

【 授权许可】

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