Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives

SCHIZOPHRENIA RESEARCH

卷:170

Article

Hochberger, W. C.¹  Hill, S. K.¹  Nelson, C. L. M.¹  Reilly, J. L.²  Keefe, R. S. E.^3,4,5  Pearlson, G. D.^6,7  Keshavan, M. S.⁸  Tamminga, C. A.⁹  Clementz, B. A.¹⁰  Sweeney, J. A.⁹ 

[1] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL 60064 USA

[2] Northwestern Univ, Dept Psychiat & Behav Sci, Evanston, IL 60208 USA

[3] Duke Univ, Dept Psychiat, Durham, NC 27706 USA

[4] Duke Univ, Dept Neurosci, Durham, NC 27706 USA

[5] Duke Univ, Dept Psychol, Durham, NC 27706 USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

[7] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA

[8] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Psychiat, Cambridge, MA 02138 USA

[9] UT Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[10] Univ Georgia, Dept Psychol, Athens, GA 30602 USA

关键词: Psychosis;    Brief Assessment of Cognition in Schizophrenia;    First-degree relatives;    Factor analysis;   

DOI  :  10.1016/j.schres.2015.11.022

来源: Elsevier

【 摘 要 】

Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognition in Schizophrenia (BACS) neuropsychological battery. Analyses were conducted on 783 psychosis spectrum probands (schizophrenia, schizoaffective, psychotic bipolar), 887 of their first-degree relatives, and 396 non-psychiatric controls from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Exploratory factor analysis of BACS subtest scores indicated a single-factor solution that was similar across all groups and provided the best overall data fit in confirmatory analyses. Correlations between the standard BACS composite score and the sum of subscale scores weighted by their loadings on this unitary factor were very high in all groups (r >=.99). Thus, the BACS assesses a similar unitary cognitive construct in probands with different psychotic disorders, in their first-degree relatives, and in healthy controls, and this factor is well measured by the test's standard composite score. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free