White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:193

Article

Subramaniam, Karuna¹  Gill, Jeevit²  Fisher, Melissa³  Mukherjee, Pratik²  Nagarajan, Srikantan²  Vinogradov, Sophia³ 

[1] Univ Calif San Francisco, Dept Psychiat, 513 Parnassus Ave,HSE604, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

关键词: Diffusion tensor imaging;    Schizophrenia;    Cognitive training;    Attention;    Executive functioning;    Prefrontal cortex;   

DOI  :  10.1016/j.schres.2017.06.062

来源: Elsevier

【 摘 要 】

We examined the relationship between white matter microstructure in schizophrenia using diffusion tensor imaging (DTI) and cognitive improvements induced by 70 h (similar to 16 weeks) of cognitive training. We measured anatomical connectivity in 48 patients with schizophrenia (SZ) and 28 healthy control participants (HC) at baseline, and then examined the relationship between anatomical connectivity at baseline and training-induced cognitive gains in 30 SZ who performed diffusion imaging after completing 70 h of training. Compared with healthy control participants, individuals with schizophrenia showed reduced white matter integrity at baseline, as indexed by fractional anisotropy metrics, in bilateral posterior corona radiata, bilateral retrolenticular internal capsules, bilateral posterior thalamic radiation, left anterior corona radiata, left superior longitudinal fasciculus, left sagittal stratum, right cerebral peduncle and the genu and splenium of the corpus callosum. After training, schizophrenia participants showed significant gains in attention/vigilance, speed of processing, verbal learning, visual learning and executive functioning. White matter integrity within the right fronto-occipital fasciculus predicted training-induced improvements in attention/vigilance, while white matter integrity within the right corticospinal tract and bilateral medial lemnisci predicted cognitive training-induced improvements in executive functioning, areas that did not show white matter tract deficits at baseline. These findings suggest that preserved white-matter integrity connecting long-range prefrontal-thalamic-sensorimotor areas may be an important determinant for training-induced neurocognitive plasticity. (c) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free