Disrupted correlation between low frequency power and connectivity strength of resting state brain networks in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:143

Article

Yu, Qingbao¹  Sui, Jing¹  Liu, Jingyu¹  Plis, Sergey M.¹  Kiehl, Kent A.^1,2  Pearlson, Godfrey^3,4,5  Calhoun, Vince D.^1,3,4,5,6 

[1] Mind Res Network, Albuquerque, NM 87106 USA

[2] Univ New Mexico, Dept Psychol, Albuquerque, NM 87106 USA

[3] Olin Neuropsychiat Res Ctr, Hartford, CT 06106 USA

[4] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[5] Yale Univ, Dept Neurobiol, New Haven, CT 06520 USA

[6] Univ New Mexico, Dept ECE, Albuquerque, NM 87106 USA

关键词: Low frequency;    Connectivity strength;    Rich club;    R-fMRI;    Schizophrenia;    Brain graph;   

DOI  :  10.1016/j.schres.2012.11.001

来源: Elsevier

【 摘 要 】

Altered brain connectivity has emerged as a central feature of schizophrenia. Low frequency oscillations and connectivity strength (CS) of resting state brain networks are altered in patients with schizophrenia (SZs). However, the relationship between these two measures has not yet been studied. Such work may be helpful in understanding the so-called rich club organization (i.e. high-CS nodes are more densely connected among themselves than are nodes of a lower CS in the human brain) in healthy controls (HCs) and SZs. Here we present a study of HCs and SZs examining low frequency oscillations and CS by first decomposing resting state fMRI (R-fMRI) data into independent components (ICs) using group independent component analysis (ICA) and computing the low frequency power ratio (LFPR) of each ICA time course. Weighted brain graphs consisting of ICs were built based on correlations between ICA time courses. Positive CS and negative CS of each node in the brain graphs were then examined. The correlations between LFPR and CSs as well as rich club coefficients of group mean brain graphs were assessed. Results demonstrate that the LFPR of some ICs were lower in SZs compared to HCs. In addition, LFPR was correlated with positive CS in HCs, but to a lesser extent in SZs. HCs showed higher normalized rich club parameter than SZs. The findings provide new insight into disordered intrinsic brain graphs in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free