Predictors of change in life skills in schizophrenia after cognitive remediation

SCHIZOPHRENIA RESEARCH

卷:107

Article

Kurtz, Matthew M.^1,2,3  Seltzer, James C.²  Fujimoto, Marco²  Shagan, Dana S.²  Wexler, Bruce E.³ 

[1] Wesleyan Univ, Dept Psychol, Middletown, CT 06459 USA

[2] Schizophrenia Rehabil Program & Resource Ctr, Inst Living, Hartford, CT 06106 USA

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA

关键词: Schizophrenia;    Cognitive remediation;    Neurocognition;    Treatment response;   

DOI  :  10.1016/j.schres.2008.10.014

来源: Elsevier

【 摘 要 】

Few studies have investigated predictors of response to cognitive remediation interventions in patients with schizophrenia. Predictor studies to date have selected treatment outcome measures that were either part of the remediation intervention itself or closely linked to the intervention with few studies investigating factors that predict generalization to measures of everyday life-skills as an index of treatment-related improvement. in the current study we investigated the relationship between four measures of neurocognitive function, crystallized verbal ability, auditory sustained attention and working memory, verbal learning and memory, and problem-solving, two measures of symptoms, total positive and negative symptoms, and the process variables of treatment intensity and duration, to change on a performance-based measure of everyday life-skills after a year of computer-assisted cognitive remediation offered as part of intensive outpatient rehabilitation treatment. Thirty-six patients with schizophrenia or schizoaffective disorder were studied. Results of a linear regression model revealed that auditory attention and working memory predicted a significant amount of the variance in change in performance-based measures of everyday life skills after cognitive remediation, even when variance for all other neurocognitive variables in the model was controlled. Stepwise regression revealed that auditory attention and working memory predicted change in everyday life-skills across the trial even when baseline life-skill scores, symptoms and treatment process variables were controlled. These findings emphasize the importance of sustained auditory attention and working memory for benefiting from extended programs of cognitive remediation. (C) 2008 Elsevier B.V. All rights reserved.

【 授权许可】

Free