Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment

SCHIZOPHRENIA RESEARCH

卷:166

Article

Hill, S. Kristian¹  Buchholz, Alison¹  Arnsbaugh, Hayley¹  Reilly, James L.²  Rubin, Leah H.³  Gold, James M.⁴  Keefe, Richard S. E.⁵  Pearlson, Godfrey D.^6,7  Keshavan, Matcheri S.⁸  Tamminga, Carol A.⁹  Sweeney, John A.⁹ 

[1] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL 60064 USA

[2] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[3] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[4] Univ Maryland, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA

[5] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA

[6] Yale Univ, Dept Psychiat & Neurobiol, New Haven, CT 06520 USA

[7] Olin Neuropsychiat Res Ctr, Hartford, CT USA

[8] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA USA

[9] Univ Texas Southwestern, Dept Psychiat, Dallas, TX USA

关键词: Schizophrenia;    Schizoaffective disorder;    Bipolar disorder;    Working memory;    B-SNIP;    Generalized cognitive deficit;    Familiality;   

DOI  :  10.1016/j.schres.2015.05.018

来源: Elsevier

【 摘 要 】

Objective: Working memory impairment is well established in psychotic disorders. However, the relative magnitude, diagnostic specificity, familiality pattern, and degree of independence from generalized cognitive deficits across psychotic disorders remain unclear. Method: Participants from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study included probands with schizophrenia (N = 289), psychotic bipolar disorder (N = 227), schizoaffective disorder (N = 165), their first-degree relatives (N = 315, N = 259, N = 193, respectively), and healthy controls (N = 289). All were administered the WMS-III Spatial Span working memory test and the Brief Assessment of Cognition in Schizophrenia (BACS) battery. Results: All proband groups displayed significant deficits for both forward and backward span compared to controls. However, after covarying for generalized cognitive impairments (BACS composite), all proband groups showed a 74% or greater effect size reduction with only schizoaffective probands showing residual backward span deficits compared to controls. Significant familiality was seen in schizophrenia and bipolar pedigrees. In relatives, both forward and backward span deficits were again attenuated after covarying BACS scores and residual backward span deficits were seen in relatives of schizophrenia patients. Conclusions: Overall, both probands and relatives showed a similar pattern of robust working memory deficits that were largely attenuated when controlling for generalized cognitive deficits. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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