Cognitive motor impairments and brain structure in schizophrenia spectrum disorder patients with a history of catatonia

SCHIZOPHRENIA RESEARCH

卷:222

Article

Dean, Derek J.¹  Woodward, Neil²  Walther, Sebastian³  McHugo, Maureen²  Armstrong, Kristan²  Heckers, Stephan² 

[1] Vanderbilt Univ, Dept Psychol, 2301 Vanderbilt Pl, Nashville, TN 37240 USA

[2] Vanderbilt Univ, Dept Psychiat & Behav Sci, Med Ctr, Nashville, TN 37240 USA

[3] Univ Bern, Univ Hosp Psychiat, Translat Res Ctr, Bern, Switzerland

关键词: Catatonia;    Psychosis;    Schizophrenia;    Cognition;    Brain structure;    Verbal fluency;    Processing speed;   

DOI  :  10.1016/j.schres.2020.05.012

来源: Elsevier

【 摘 要 】

There is growing interest in understanding the behavioral and neural mechanisms of catatonia. Here, we examine cognition and brain structure in schizophrenia spectrum disorder (SSD) patients with a history of catatonia. A total of 172 subjects were selected from a data repository; these included SSD patients with (n = 43) and without (n = 43) a history of catatonia and healthy control subjects (n = 86). Cognitive functioning was assessed using the Screen for Cognitive Impairment in Psychiatry (SCIP) and brain structure was assessed using voxel-based morphometry (VBM) in the CAT12 toolbox. SSD patients with a history of catatonia showed worse performance on tests of verbal fluency and processing speed compared to SSD patients without such a history, even after controlling for current antipsychotic and benzodiazepine use. No differences were found between patients with and without a history of catatonia in terms of brain structure. Both patient groups combined showed significantly smaller grey matter volumes compared to healthy control subjects in brain regions consistent with prior studies, including the anterior cingulate, insular, temporal, and medial frontal cortices. The results highlight a cognitive-motor impairment in SSD patients with a history of catatonia. Challenges and limitations of examining brain structure in patients with a history of catatonia are discussed. (c) 2020 Elsevier B.V. All rights reserved.

【 授权许可】

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