A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence

SCHIZOPHRENIA RESEARCH

卷:152

Article

Khandaker, Golam M.^1,2,3  Zammit, Stanley^3,4  Lewis, Glyn^3,5  Jones, Peter B.^1,2 

[1] Univ Cambridge, Dept Psychiat, Cambridge CB2 2QQ, England

[2] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England

[3] Univ Bristol, Sch Social & Community Med, Ctr Mental Hlth Addict & Suicide Res, Bristol BS8 1TH, Avon, England

[4] Cardiff Univ, Ctr Neuropsychiat Genet & Genom, MRC, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales

[5] UCL, London, England

关键词: Atopic disorders;    Asthma;    Eczema;    Childhood;    Adolescence;    Psychotic experiences;    Psychotic symptoms;    Schizophrenia;    Inflammatory markers;    IL-6;    CRP;    Cytokine;    Immunity;    Birth cohort;    Prospective study;    ALSPAC;   

DOI  :  10.1016/j.schres.2013.09.021

来源: Elsevier

【 摘 要 】

Objective: Schizophrenia is associated with atopy and increased inflammatory markers. We report a population-based longitudinal study of the associations between childhood atopic disorders, subsequent serum inflammatory markers, interleukin 6 (IL-6) and C-reactive protein (CRP), and the risk of psychotic experiences (PEs). Method: PEs were assessed at age 13 years (n = 6785). Presence of clinician-diagnosed atopic disorders (asthma and eczema) was determined from parent-completed questionnaires at age 10 years (n = 7814). Serum IL-6 and CRP were measured at age 9 years (n = 5076). Logistic regression examined the association between (1) atopy and PEs, (2) inflammatory markers and PEs, and (3) mediating effects of inflammatory markers on the atopy-PEs association. Linear regression examined the association between atopy and inflammatory markers. Age, gender, social class, ethnicity and body mass index were included as potential confounders. Results: At age 10 years, about 14% of the sample was reported to have asthma, 12% eczema, and 7% both asthma and eczema. Compared with children with no atopy, risk of PEs at age 13 years was increased for all of these groups; adjusted odds ratios (95% CI) were, respectively, 1.39 (1.10-1.77), 1.33 (1.04-1.69), and 1.44 (1.06-1.94). Atopy was associated with increased serum IL-6 and CRP; however, this did not mediate association between atopy and PEs. Inflammatory markers were not associated with later PEs. Conclusion: Childhood atopic disorders increase the risk of psychotic experiences in adolescence. Follow-up of these individuals will be useful to determine the effect of atopy and inflammation on different trajectories of early-life PEs. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free