Persistent tachycardia in clozapine treated patients: A 24-hour ambulatory electrocardiogram study

SCHIZOPHRENIA RESEARCH

卷:199

Article

Nilsson, Bjorn M.¹  Lindstrom, Leif¹  Mohsen, Issam²  Holmlov, Karolina¹  Boden, Robert¹ 

[1] Uppsala Univ, Dept Neurosci, Psychiat, SE-75185 Uppsala, Sweden

[2] Uppsala Univ, Dept Med Sci, Clin Physiol, SE-75185 Uppsala, Sweden

关键词: Schizophrenia;    Clozapine;    Tachycardia;    Heart rate;    Cardiovascular health;    Holter ECG;   

DOI  :  10.1016/j.schres.2018.03.017

来源: Elsevier

【 摘 要 】

Tachycardia is associated with cardiovascular mortality. Tachycardia is also a known clozapine adverse effect. However, whether clozapine-associated tachycardia is persistent is not known. Thirty clozapine-treated patients with clinical tachycardia were investigated with 24-hour ambulatory electrocardiography (ECG). Baseline peripheral heart rate (HR) was 106.7 +/- 7.8. The ambulatory ECG 24-hour-HR was 98.7 +/- 9.7. Baseline HR and 24-hour-HR correlated strongly (r = 0.74, p = 0.000003). Daytime HR was 106.4 +/- 9.9 and nighttime HR 89.2 +/- 12.0. Low dose bisoprolol reduced HR significantly. The high 24-hour-HR indicates a persistent tachycardia. Tachycardia should not discourage from clozapine use but the findings indicate a need of guidelines for detection and treatment of clozapine-associated tachycardia. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:creativecommons.org/licenses/by-nc-nd/4.0/).

【 授权许可】

Free