Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients

SCHIZOPHRENIA RESEARCH

卷:98

Article

Weickert, Cynthia Shannon^1,2  Rothmond, Debora A.²  Hyde, Thomas A.³  Kleinman, Joel E.³  Straub, Richard E.⁴ 

[1] Univ New S Wales, Prince Wales Med Res Inst, Schizophrenia Res Inst, Dept Psychiat, Randwick, NSW 2031, Australia

[2] NIMH, MiNDS Unit, Clin Brain Disorders Branch, IRP,NIH, Bethesda, MD 20892 USA

[3] NIMH, Neuropathol Sect, Clin Brain Disorders Branch, IRP,NIH, Bethesda, MD 20892 USA

[4] NIMH, Genes Cognit & Psychosis Program, IRP, NIH, Bethesda, MD 20892 USA

关键词: schizophrenia;    postmortem;    hippocampus;    spinophilin;    synaptophysin;    candidate gene;    synapse;    synaptic pathology;   

DOI  :  10.1016/j.schres.2007.05.041

来源: Elsevier

【 摘 要 】

Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia. (C) 2007 Elsevier B.V. All rights reserved.

【 授权许可】

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