Sleep correlates of cognition in early course psychotic disorders

SCHIZOPHRENIA RESEARCH

卷:131

Article

Keshavan, Matcheri S.^1,2  Montrose, Debra M.¹  Miewald, Jean M.¹  Jindal, Ripu D.¹ 

[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

关键词: Sleep;    Spindles;    Slow waves;    Cognition;    Schizophrenia;    Psychosis;   

DOI  :  10.1016/j.schres.2011.05.027

来源: Elsevier

【 摘 要 】

Background: Slow waves and sleep spindles, the main oscillations during non-rapid eye movement sleep, have been thought to be related to cognitive processes, and are impaired in psychotic disorders. Cognitive impairments, seen early in the course of psychotic disorders, may be related to alterations in these oscillations, but few studies have examined this relationship. Method: Twenty seven untreated patients with a recently diagnosed psychotic disorder had polysomno-graphic sleep studies and neuro-cognitive testing. Results: Reduced power in the sigma range, which reflects spindle density, was associated with impaired attention, and reasoning, but not intelligence quotient (IQ). Slow wave sleep measures were not significantly associated with any cognitive measures. Conclusions: Impairments in sleep spindles may be associated with cognitive deficits in the early course of psychotic disorders. These observations may help clarify neuro-biologic mechanisms of cognitive deficits in psychotic disorders such as schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free