Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

SCHIZOPHRENIA RESEARCH

卷:208

Article

Faria, Andreia V.¹  Crawford, Jeffrey²  Ye, Chenfei⁶  Hsu, Johnny¹  Kenkare, Anshel²  Schretlen, David^1,2  Sawa, Akira^2,3,4,5 

[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Mental Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[6] Harbin Inst Technol, Shenzhen Grad Sch, Dept Elect & Informat, Shenzhen, Guangdong, Peoples R China

关键词: DTI;    First-episode psychosis;    Schizophrenia;    Cognition;    MRI;   

DOI  :  10.1016/j.schres.2019.04.010

来源: Elsevier

【 摘 要 】

We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition ( processing speed, attention/ working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus). (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

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