Diffusion tensor imaging study of the fornix in first episode schizophrenia and in healthy controls

SCHIZOPHRENIA RESEARCH

卷:156

Article

Fitzsimmons, J.^1,2  Hamoda, H. M.^1,2,3  Swisher, T.^1,2  Terry, D.^1,2  Rosenberger, G.^1,2,4  Seidman, L. J.^5,6  Goldstein, J.^5,7  Mesholam-Gately, R.⁵  Petryshen, T.^8,9  Wojcik, J.⁵  Kikinis, R.¹⁰  Kubicki, M.¹⁰ 

[1] Harvard Univ, Sch Med, Dept Psychiat, Psychiat Neuroimaging Lab,Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Radiol, Psychiat Neuroimaging Lab,Brigham & Womens Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Psychiat, Boston Childrens Hosp, Boston, MA 02115 USA

[4] Med Univ Innsbruck, Dept Gen Psychiat, A-6020 Innsbruck, Austria

[5] Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Beth Israel Deaconess Med Ctr,Publ Psychiat Div, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA USA

[8] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA

[9] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Ctr Human Genet Res, Boston, MA 02114 USA

[10] Harvard Univ, Sch Med, Dept Radiol, Surg Planning Lab,MRI Div,Brigham & Womens Hosp, Boston, MA 02115 USA

关键词: First episode schizophrenia;    Fornix;    Diffusion tensor imaging;    Fractional anisotropy;    Trace;    Axial diffusivity;    Radial diffusivity;   

DOI  :  10.1016/j.schres.2014.04.022

来源: Elsevier

【 摘 要 】

Background: The fornix is a compact bundle of white matter fibers that project from the hippocampus to the mamillary bodies and septal nuclei. Its association with memory, as well as with symptoms in schizophrenia, has been reported in chronic schizophrenia. The purpose of this study is to determine whether or not fornix abnormalities are evident at the onset of schizophrenia. Methods: Diffusion tensor imaging (DTI) and DT tractography were used to evaluate the fornix in 21 patients with first episode schizophrenia (16 males/5 females) and 22 healthy controls (13 males/9 females). Groups were matched on age, gender, parental socioeconomic status, education and handedness. Fractional anisotropy (FA), a measure of white matter integrity, radial diffusivity (RD), thought to reflect myelin integrity, trace, a possible marker of atrophy or cell loss, and axial diffusivity (AD), thought to reflect axonal integrity, were averaged over the entire tract extracted by means of DT tractography, and used to investigate fornix abnormalities in first episode schizophrenia compared with healthy controls. Results: Significant group differences were found between first episode patients and controls for FA (p = 0.0001), RD (p = 0.001) and trace (p = 0.006). Conclusion: These findings suggest abnormalities in the fornix in the early stages of schizophrenia, and further suggest that white matter abnormalities, which are apparent in the early course of the disease, may reflect myelin disturbances. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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