Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

SCHIZOPHRENIA RESEARCH

卷:169

Article

Bachiller, Alejandro¹  Romero, Sergio^2,3  Molina, Vicente^4,5  Alonso, Joan F.^2,3  Mananas, Miguel A.^2,3  Poza, Jesus^1,5,6  Hornero, Roberto⁶ 

[1] Univ Valladolid, ETS Ingenieros Telecomunicac, Biomed Engn Grp, E-47011 Valladolid, Spain

[2] Univ Politecn Cataluna, CREB, Dept Automat Control ESAII, E-08028 Barcelona, Spain

[3] Biomed Res Networking Ctr Bioengn Biomat & Nanome, CIBER BBN, Barcelona, Spain

[4] Univ Valladolid, Fac Med, Hosp Clin Univ, Dept Psychiat, E-47005 Valladolid, Spain

[5] Univ Salamanca, Inst Neurociencias Castilla & Leon, INCYL, Salamanca 37007, Spain

[6] Univ Valladolid, Inst Invest Matemat, IMUVA, E-47011 Valladolid, Spain

关键词: Schizophrenia;    Loreta;    Source localization;    Event-related potentials;    Window of interest;    P3a and P3b;   

DOI  :  10.1016/j.schres.2015.09.028

来源: Elsevier

【 摘 要 】

The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by time-averaging of low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects' P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes, whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in a cognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitive processes and underlying mechanisms in Sz. (C) 2015 Elsevier B.V. All rights reserved.

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