Individual negative symptoms and domains - Relevance for assessment, pathomechanisms and treatment

SCHIZOPHRENIA RESEARCH

卷:186

Review

Kaiser, Stefan¹  Lyne, John^2,3,4  Agartz, Ingrid^5,6,7  Clarke, Mary^4,8  Morch-Johnsen, Lynn^5,6,7  Faerden, Ann^6,7,9 

[1] Univ Zurich, Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, Lenggstr 31, CH-8032 Zurich, Switzerland

[2] Royal Coll Surgeons Ireland, 123 St Stephens Green, Dublin 2, Ireland

[3] Ashlin Ctr, North Dublin Mental Hlth Serv, Beaumont Rd, Dublin 9, Ireland

[4] Dublin & East Treatment & Early Care Team DETECT, Dublin, Ireland

[5] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[6] Univ Oslo, NORMENT, N-0424 Oslo, Norway

[7] Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, N-0424 Oslo, Norway

[8] Univ Coll Dublin, Coll Life Sci, Dublin, Ireland

[9] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

关键词: Negative symptoms;    Apathy;    Diminished expression;    Avolition;    Amotivation;    Blunted affect;   

DOI  :  10.1016/j.schres.2016.07.013

来源: Elsevier

【 摘 要 】

The negative symptoms of schizophrenia can be divided into two domains. Avolition/apathy includes the individual symptoms of avolition, asociality and anhedonia. Diminished expression includes blunted affect and alogia. Until now, causes and treatment of negative symptoms have remained a major challenge, which is partially related to the focus on negative symptoms as a broad entity. Here, we propose that negative symptoms may become more tractable when the different domains and individual symptoms are taken into account. There is now increasing evidence that the relationship with clinical variables - in particular outcome - differs between the domains of avolition/apathy and diminished expression. Regarding models of negative symptom formation, those relevant to avolition/apathy are now converging on processes underlying goal-directed behavior and dysfunctions of the reward system. In contrast, models of the diminished expression domains are only beginning to emerge. The aim of this article is to review the specific clinical, behavioral and neural correlates of individual symptoms and domains as a better understanding of these areas may facilitate specific treatment approaches. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free