Regulation ofmitochondrial dynamics by DISC1, a putative risk factor for major mental illness

SCHIZOPHRENIA RESEARCH

卷:187

Review

Murphy, Laura C.¹  Millar, J. Kirsty¹ 

[1] Univ Edinburgh, MRC Inst Genet & Mol Med, Ctr Genom & Expt Med, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

关键词: Mitochondrial dynamics;    Mitochondrial trafficking;    DISC1;    NDE1;    TRAK1/2;    GSK3 beta;   

DOI  :  10.1016/j.schres.2016.12.027

来源: Elsevier

【 摘 要 】

Mitochondria are dynamic organelles that are essential to power the process of neurotransmission. Neurons must therefore ensure that mitochondria maintain their functional integrity and are efficiently transported along the full extent of the axons and dendrites, from soma to synapses. Mitochondrial dynamics (trafficking, fission and fusion) co-ordinately regulate mitochondrial quality control and function. DISC1 is a component of the mitochondrial transportmachinery and regulates mitochondrial dynamics. DISC1's role in this is adversely affected by sequence variants connected to brain structure/function and disease risk, and by mutant truncation. The DISC1 interactors NDE1 and GSK3 beta are also involved, indicating a convergence of putative risk factors for psychiatric illness upon mitochondrial dynamics. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free