Latent class cluster analysis of symptom ratings identifies distinct subgroups within the clinical high risk for psychosis syndrome

SCHIZOPHRENIA RESEARCH

卷:197

Article

Ryan, Arthur T.¹  Addington, Jean²  Bearden, Carrie E.^3,4  Cadenhead, Kristin S.⁵  Cornblatt, Barbara A.⁶  Mathalon, Daniel H.^7,14  McGlashan, Thomas H.⁸  Perkins, Diana O.⁹  Seidman, Larry J.^10,11  Tsuang, Ming T.⁵  Woods, Scott W.⁸  Cannon, Tyrone D.^8,12  Walker, Elaine F.^1,13 

[1] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[2] Univ Calgary, Dept Psychiat, Calgary, AB, Canada

[3] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[5] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA

[6] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[7] UCSF, Dept Psychiat, San Francisco, CA USA

[8] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[9] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA

[10] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA USA

[11] Massachusetts Gen Hosp, Boston, MA 02114 USA

[12] Yale Univ, Dept Psychol, New Haven, CT USA

[13] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[14] SFVA Med Ctr, San Francisco, CA USA

关键词: Schizophrenia;    Prodrome;    Finite mixture models;    Disorganization symptoms;    Heterogeneity;   

DOI  :  10.1016/j.schres.2017.12.001

来源: Elsevier

【 摘 要 】

The clinical-high-risk for psychosis (CHR-P) syndrome is heterogeneous in terms of clinical presentation and outcomes. Identifyingmore homogenous subtypes of the syndrome may help clarify its etiology and improve the prediction of psychotic illness. This study applied latent class cluster analysis (LCCA) to symptom ratings from the North American Prodrome Longitudinal Studies 1 and 2 (NAPLS 1 and 2). These analyses produced evidence for three to five subgroups within the CHR-P syndrome. Differences in negative and disorganized symptoms distinguished among the subgroups. Subgroup membership was found to predict conversion to psychosis. The authors contrast themethods employed within this study with previous attempts to identify more homogenous subgroups of CHR-P individuals and discuss how these results could be tested in future samples of CHR-P individuals. Published by Elsevier B.V.

【 授权许可】

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