Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

SCHIZOPHRENIA RESEARCH

卷:217

Article

Dennison, Charlotte A.¹  Legge, Sophie E.¹  Pardinas, Antonio F.¹  Walters, James T. R.¹ 

[1] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Hadyn Ellis Bldg,Maindy Rd, Cardiff CF24 4HQ, Wales

关键词: Schizophrenia;    GWAS;    Prediction;    Annotation;    Polygenic risk;   

DOI  :  10.1016/j.schres.2019.10.048

来源: Elsevier

【 摘 要 】

Genome-wide association studies (GWAS) have proved to be a powerful approach for gene discovery in schizophrenia; their findings have important implications not just for our understanding of the genetic architecture of the disorder, but for the potential applications of personalised medicine through improved classification and targeted interventions. In this article we review the current status of the GWAS literature in schizophrenia including functional annotation methods and polygenic risk scoring, as well as the directions and challenges of future research. We consider recent findings in East Asian populations and the advancements from trans-ancestry analysis, as well as the insights gained from research looking across psychiatric disorders. (C) 2019 Published by Elsevier B.V.

【 授权许可】

Free