One-year durability of the effects of cognitive enhancement therapy on functional outcome in early schizophrenia

SCHIZOPHRENIA RESEARCH

卷:120

Article

Eack, Shaun M.^1,2  Greenwald, Deborah P.²  Hogarty, Susan S.²  Keshavan, Matcheri S.^2,3,4 

[1] Univ Pittsburgh, Sch Social Work, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA 15260 USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

关键词: Schizophrenia;    Cognitive rehabilitation;    Cognition;    Neurocognition;    Social cognition;    Early intervention;   

DOI  :  10.1016/j.schres.2010.03.042

来源: Elsevier

【 摘 要 】

Cognitive rehabilitation is an effective intervention for addressing cognitive impairments in patients with schizophrenia. Previous research has shown that the early application of Cognitive Enhancement Therapy (CET) can improve neurocognitive and social-cognitive deficits in the early course of the disorder, and ultimately reduce the substantial functional disability that these patients experience. However, the lasting effects of CET on functional outcome in early course schizophrenia patients remain unknown. In this study, 58 patients in the early course of schizophrenia or schizoaffective disorder treated with 2 years of either CET or an Enriched Supportive Therapy (EST) control were followed-up 1 year after the completion of treatment to examine the durability of CET effects on functional outcome. At one-year post-treatment, a high (72%) retention rate was observed in both treatments. Results from intent-to-treat analyses employing linear mixed-effects models indicated that CET effects on functional outcome were broadly maintained one-year post-treatment, and that patients receiving CET continued to demonstrate highly significant differential functional benefits compared to patients treated with EST. These findings support the durability of CET effects on functional outcome in the early course of schizophrenia, and point to the potential of cognitive rehabilitation to have a lasting impact on the early trajectory of the disorder. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free