Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis

SCHIZOPHRENIA RESEARCH

卷:140

Article

Hsieh, Ming H.^1,2,3,4,8  Shan, Jia-Chi^1,3,5  Huang, Wei-Lieh^1,2,3  Cheng, Wan-Chen⁶  Chiu, Ming-Jang^4,7  Jaw, Fu-Shan^4,8  Hwu, Hai-Gwo^1,3,4  Liu, Chen-Chung^1,3 

[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan

[2] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Psychiat, Dou Liou City, Yun Lin, Taiwan

[3] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[4] Natl Taiwan Univ, Neurobiol & Cognit Sci Ctr, Taipei 10764, Taiwan

[5] Cathay Gen Hosp, Dept Psychiat, Taipei, Taiwan

[6] Min Shin Clin, Taipei, Taiwan

[7] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan

[8] Natl Taiwan Univ, Inst Biomed Engn, Taipei 10764, Taiwan

关键词: Mismatch negativity;    P50;    N100;    Schizophrenia;    Pre-psychotic state;   

DOI  :  10.1016/j.schres.2012.06.021

来源: Elsevier

【 摘 要 】

Background: Recent schizophrenia research exploring the complicated pathogenesis of schizophrenia has focused on the subjects with at-risk mental states in order to exclude the influence of confounding factors. This study explores 3 sets of auditory-related event potentials in subjects with different risk levels of psychosis. Methods: Subjects were recruited from the SOPRES study in Taiwan. P50 and N100 using an auditory paired-click paradigm and duration MMN were assessed on 32 first-episode psychosis (FEP), 30 ultra-high risk (UHR), 37 E-BARS (early/broad at-risk mental states) participants and 56 controls. Results: MMN was correlated with neither P50 nor N100, whereas many parameters of the latter two were inter-correlated with each other. Compared to healthy controls, MMNs were significantly lower in all 3 clinical groups (E-BARS, UHR and FEP). A gradient of sensory-gating deficits, manifested by increased P50 ratios (S2/S1) and decreased N100 differences, across different levels of clinical severity was suggested by a linear trend. For the UHR subjects, P50 gating ratio, N100 gating ratio, N100 difference, and N100 S2 amplitude might be potential indicators to discriminate converters from non-converters. Conclusions: By including subjects with E-BARS, our results provide new insight regarding pre-attentive auditory event-related potential in subjects across different risk levels of psychotic disorders. Impaired deviance detection shown by MMNs already exists in people at a pre-psychotic state regardless of clinical severity, while sensory-gating deficits shown by P50/N100 varies depending on the risk levels in prodromal period. Further longitudinal research exploring the relationship between ERPs and subjects with a suspected pre-psychotic state is needed. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free