Quality of life in stable schizophrenia: The relative contributions of disorganization and cognitive dysfunction

SCHIZOPHRENIA RESEARCH

卷:153

Article

Sigaudo, Monica¹  Crivelli, Barbara¹  Castagna, Filomena¹  Giugiario, Michela¹  Mingrone, Cinzia¹  Montemagni, Cristiana¹  Rocca, Giuseppe¹  Rocca, Paola¹ 

[1] Univ Turin, Dept Neurosci, Psychiat Sect, I-10126 Turin, Italy

关键词: Schizophrenia;    Quality of life;    Disorganization;    Cognitive dysfunction;    Mediation analysis;   

DOI  :  10.1016/j.schres.2014.01.013

来源: Elsevier

【 摘 要 】

Objective: The purpose of this study was to examine the relative contributions of disorganization and cognitive dysfunction to quality of life (QOL) in patients with stable schizophrenia. Methods: A total of 276 consecutive outpatients with stable schizophrenia were enrolled in a cross-sectional study. We performed a mediation analysis to assess the specific effect of disorganization on QOL, as assessed by the Heinrichs-Carpenter Quality of Life Scale (QLS), and the possible mediating role of cognitive dysfunction. Results: Our findings were as follows: (i) disorganization was negatively related to the total QLS score; (ii) disorganization was negatively related to two of the four QLS domains, namely the role-functioning domain (occupational/educational) and the intrapsychic functioning domain (e. g., motivation, curiosity, and empathy); and (iii) verbal memory was a partial mediator of the relationship between disorganization and QLS (the total score and the two above-mentioned domains). Conclusions: Disorganization demonstrated direct and indirect effects via verbal memory on two domains of functioning, as measured by the QLS. These results highlight the importance of improving disorganization and cognition (particularly verbal memory) to improve the functional outcomes of patients with schizophrenia. (C) 2014 Elsevier B. V. All rights reserved.

【 授权许可】

Free