Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life

SCHIZOPHRENIA RESEARCH

卷:222

Article

Scoriels, Linda^1,2,3  Genaro, Larissa T.^1,2  Mororo, Luana G. C.^1,2  Keffer, Stella^1,2  Guimaraes, Anna Luiza D., V^1,2  Ribeiro, Paulo V. S.^1,2  Tannos, Filippe M.^1,2  Novaes, Caroline^1,2  Franca, Aniela, I⁴  Goldenstein, Nelson²  Sahakian, Barbara J.³  Cavalcanti, Maria T.²  Fisher, Melissa⁵  Vinogradov, Sophia⁵  Panizzutti, Rogerio^1,2 

[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Psiquiatr, Rio De Janeiro, Brazil

[3] Univ Cambridge, Dept Psychiat, Cambridge, England

[4] Univ Fed Rio de Janeiro, Fac Letras, Rio De Janeiro, Brazil

[5] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

关键词: Schizophrenia;    Cognitive training;    Visual training;    Auditory training;    Neuroplasticity;    Computerized training;   

DOI  :  10.1016/j.schres.2020.05.017

来源: Elsevier

【 摘 要 】

Background: Cognitive impairments are related to deficits in primary auditory and visual sensory processes in schizophrenia. These impairments can be remediated by neuroscience-informed computerized cognitive trainings that target auditory and visual processes. However, it is not clear which modality results in greater improvements in cognition, symptoms and quality of life. We aimed to investigate the impact of training auditory versus visual cognitive processes in global cognition in patients with schizophrenia. Methods: Seventy-nine schizophrenia participants were randomly assigned to either 40 h of auditory or visual computerized training. Auditory and visual exercises were chosen to be dynamically equivalent and difficulties increased progressively during the training. We evaluated cognition, symptoms and quality of life before, after 20 h, and after 40 h of training. ClinicalTrials.gov (1R03TW009002-01). Results: Participants who received the visual training showed significant improvements in global cognition compared to the auditory training group. The visual training significantly improved attention and reasoning and problem-solving, while the auditory training improved reasoning and problem-solving only. Schizophrenia symptoms improved after training in both groups, whereas quality of life remained unchanged. Interestingly, there was a significant and positive correlation between improvements in attention and symptoms in the visual training group. Conclusions: We conclude that the visual training and the auditory training are differentially efficient at remediating cognitive deficits and symptoms of clinically stable schizophrenia patients. Ongoing follow-up of participants will evaluate the durability of training effects on cognition and symptoms, as well as the potential impact on quality of life over time. (c) 2020 Elsevier B.V. All rights reserved.

【 授权许可】

Free