The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study

SCHIZOPHRENIA RESEARCH

卷:236

Article

Ferraro, Laura¹  La Cascia, Caterina¹  La Barbera, Daniele¹  Sanchez-Gutierrez, Teresa²  Tripoli, Giada¹  Seminerio, Fabio¹  Sartorio, Crocettarachele¹  Marrazzo, Giovanna¹  Sideli, Lucia¹  Arango, Celso³  Arrojo, Manuel⁴  Bernardo, Miguel⁵  Bobes, Julio⁶  Del-Ben, Cristina Marta⁷  Gayer-Anderson, Charlotte⁸  Jongsma, Hannah E.⁹  Kirkbride, James B.⁹  Lasalvia, Antonio¹⁰  Tosato, Sarah¹¹  Llorca, Pierre-Michel¹²  Menezes, Paulo Rossi¹³  Rutten, Bart P.¹⁴  Santos, Jose Luis¹⁵  Sanjuan, Julio¹⁶  Selten, Jean-Paul^14,17  Szoke, Andrei¹⁸  Tarricone, Ilaria¹⁹  Muratori, Roberto²⁰  Tortelli, Andrea²¹  Velthorst, Eva^22,23  Rodriguez, Victoria²⁴  Quattrone, Andrea²⁵  Jones, Peter B.^26,27  Van Os, Jim^24,28  Vassos, Evangelos²⁹  Morgan, Craig⁸  de Haan, Lieuwe³⁰  Reininghaus, Ulrich^8,14,31  Cardno, Alastair G.³²  Di Forti, Marta^29,33  Murray, Robin M.^24,33  Quattrone, Diego^29,31,33 

[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BiND, Sect Psychiat, Via G La Loggia 1, I-90129 Palermo, Italy

[2] Univ Int La Rioja UNIR, Fac Hlth Sci, Logrono, Spain

[3] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Dept Child & Adolescent Psychiat,IiSGM CIBERSAM, C Doctor Esquerdo 46, Madrid 28007, Spain

[4] Complejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria Santiago de Compostela, Dept Psychiat, Psychiat Genet Grp, Santiago, Spain

[5] Univ Barcelona, Hosp Clin, Neurosci Inst,IDIBAPS,CIBERSAM, Dept Med,Barcelona Clin,Schizophrenia Unit, Barcelona, Spain

[6] Univ Oviedo, Ctr Invest Biomed Red Salud Mental CIBERSAM, Sch Med, Dept Med,Psychiat Area, C Julian Claveria S-N, Oviedo 33006, Spain

[7] Univ Sao Paulo, Fac Med FMUSP, Dept Preventat Med, Sao Paulo, Brazil

[8] Kings Coll London, Inst Psychiat, Dept Hlth Serv & Populat Res, De Crespigny Pk,Denmark Hill, London SE5 8AF, England

[9] UCL, Div Psychiat, Psylife Grp, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England

[10] Azienda Osped Univ Integrata Verona, Sect Psychiat, Verona, Italy

[11] Univ Verona, Dept Neurosci Biomed & Movement, Sect Psychiat, Piazzale LA Scuro 10, I-37134 Verona, Italy

[12] Univ Clermont Auvergne, EA 7280, F-63000 Clermont Ferrand, France

[13] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil

[14] Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, South Limburg Mental Hlth Res & Teaching Network, POB 616, NL-6200 MS Maastricht, Netherlands

[15] Hosp Virgen de la Luz, Dept Psychiat, Serv Psiquiatria, Cuenca 16002, Spain

[16] Univ Valencia, Ctr Invest Biomed Red Salud Mental CIBERSAM, Sch Med, Dept Psychiat, C Avda Blasco Ibanez 15, Valencia 46010, Spain

[17] Rivierduinen Inst Mental Hlth Care, Sandifortdreef 19, NL-2333 ZZ Leiden, Netherlands

[18] INSERM, U955, Equipe 15, 51 Ave Marechal de Lattre de Tassigny, F-94010 Creteil, France

[19] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Psychiat Unit, Viale Pepoli 5, I-40126 Bologna, Italy

[20] Bologna Local Hlth Author, Dapt Mental Hlth & Pathol Addict, Bologna, Italy

[21] Etab Publ Sante Maison Blanche, F-75020 Paris, France

[22] Univ Amsterdam, Dept Psychiat, Early Psychosis Sect, Amsterdam UMC, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands

[23] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[24] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk,Denmark Hill, London SE5 8AF, England

[25] Villa Betania Inst, Natl Hlth Serv, Reggio Di Calabria, Italy

[26] Univ Cambridge, Dept Psychiat, Cambridge, England

[27] Cambridgeshire & Peterborough NHS Fdn Trust, CAMEO Early Intervent Serv, Cambridge CB21 5EF, England

[28] Utrecht Univ Med Ctr, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

[29] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London SE5 8AF, England

[30] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Early Psychosis Sect, Amsterdam, Netherlands

[31] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany

[32] Univ Leeds, Acad Unit Psychiat & Behav Sci, Leeds, W Yorkshire, England

[33] South London & Maudsley NHS Mental Hlth Fdn Trust, London, England

关键词: First episode psychosis;    Symptom dimensions;    Transdiagnostic;    Premorbid adjustment;    Cognitive domains;    IQ;   

DOI  :  10.1016/j.schres.2021.08.008

来源: Elsevier

【 摘 要 】

Premorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample. We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom dimensions and PSF, PAF, and IQ, having age, sex, country, self-ascribed ethnicity and frequency of cannabis use as confounders. In 785 patients, better PSF was associated with fewer negative (B =-0.12, 95% C.I.-0.18,-0.06, p < 0.001) and depressive (B =-0.09, 95% C.I.-0.15,-0.03, p = 0.032), and more manic (B = 0.07, 95% C.I. 0.01, 0.14, p = 0.023) symptoms. Patients with a lower IQ presented with slightly more negative and positive, and fewer manic, symptoms. Secondary analysis on IQ subdomains revealed associations between better perceptual reasoning and fewer negative (B =-0.09, 95% C.I.-0.17,-0.01, p = 0.023) and more manic (B = 0.10, 95% C. I. 0.02, 0.18, p = 0.014) symptoms. Fewer positive symptoms were associated with better processing speed (B =-0.12, 95% C.I.-0.02,-0.004, p = 0.003) and working memory (B =-0.10, 95% C.I.-0.18,-0.01, p = 0.024). These findings suggest that the negative and manic symptom dimensions may serve as clinical proxies of

【 授权许可】

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