The associations between multisensory temporal processing and symptoms of schizophrenia

SCHIZOPHRENIA RESEARCH

卷:179

Article

Stevenson, Ryan A.^1,2  Noel, Jean-Paul⁴  Barense, Morgan D.^5,6  Ferber, Susanne^5,6  Wallace, Mark T.^4,7,8,3,9 

[1] Univ Western Ontario, Dept Psychol, London, ON, Canada

[2] Univ Western Ontario, Brain & Mind Inst, London, ON, Canada

[3] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA

[4] Vanderbilt Univ, Vanderbilt Brain Inst, 221 Kirkland Hall, Nashville, TN 37235 USA

[5] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[6] Rotman Res Inst, Toronto, ON, Canada

[7] Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, Nashville, TN USA

[8] Vanderbilt Univ, Med Ctr, Vanderbilt Kennedy Ctr, Nashville, TN USA

[9] Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN USA

关键词: Multisensory integration;    Schizophrenia;    Temporal processing;    Speech perception;    Hallucinations;    Audiovisual;   

DOI  :  10.1016/j.schres.2016.09.035

来源: Elsevier

【 摘 要 】

Recent neurobiological accounts of schizophrenia have included an emphasis on changes in sensory processing. These sensory and perceptual deficits can have a cascading effect onto higher-level cognitive processes and clinical symptoms. One form of sensory dysfunction that has been consistently observed in schizophrenia is altered temporal processing. In this study, we investigated temporal processing within and across the auditory and visual modalities in individuals with schizophrenia (SCZ) and age-matched healthy controls. Individuals with SCZ showed auditory and visual temporal processing abnormalities, as well as multisensory temporal processing dysfunction that extended beyond that attributable to unisensory processing dysfunction. Most importantly, these multisensory temporal deficits were associated with the severity of hallucinations. This link between atypical multisensory temporal perception and clinical symptomatology suggests that clinical symptoms of schizophrenia may be at least partly a result of cascading effects from (multi) sensory disturbances. These results are discussed in terms of underlying neural bases and the possible implications for remediation. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free