Childhood exposure to green space - A novel risk-decreasing mechanism for schizophrenia?

SCHIZOPHRENIA RESEARCH

卷:199

Article

Kristine, Engemann^1,2  Bocker, Pedersen Carsten^2,3,4  Lars, Arge⁵  Constantinos, Tsirogiannis⁵  Bo, Mortensen Preben^2,3,4  Jens-Christian, Svenning¹ 

[1] Aarhus Univ, Dept Biosci, Sect Ecoinformat & Biodivers, Ny Munkegade 114, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, CIRRAU, Ctr Integrated Register Based Res, DK-8210 Aarhus V, Denmark

[3] Aarhus Univ, Dept Econ & Business Econ, Aarhus BSS, Natl Ctr Register Based Res, DK-8210 Aarhus V, Denmark

[4] Aarhus Univ, iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, DK-8210 Aarhus V, Denmark

[5] Aarhus Univ, Dept Comp Sci, MADALGO, Ctr Mass Data Algorithm, Aarhus N, Denmark

关键词: Health geography;    Incidence rate ratio;    Mental health;    Normalized difference vegetation index;    Prospective study;    Survival analyses;   

DOI  :  10.1016/j.schres.2018.03.026

来源: Elsevier

【 摘 要 】

Schizophrenia risk has been linked to urbanization, but the underlying mechanism remains unknown. Green space is hypothesized to positively influence mental health and might mediate risk of schizophrenia by mitigating noise and particle pollution exposure, stress relief, or other unknown mechanisms. The objectives for this study were to determine if green space are associated with schizophrenia risk, and if different measures of green space associate differently with risk. We used satellite data from the Landsat program to quantify green space in a new data set for Denmark at 30 x 30 m resolution for the years 1985-2013. The effect of green space at different ages and within different distances from each person's place of residence on schizophrenia risk was estimated using Cox regression on a very large longitudinal population-based sample of the Danish population (943,027 persons). Living at the lowest amount of green space was associated with a 1.52-fold increased risk of developing schizophrenia compared to persons living at the highest level of green space. This association remained after adjusting for known risk factors for schizophrenia: urbanization, age, sex, and socioeconomic status. The strongest protective association was observed during the earliest childhood years and closest to place of residence. This is the first nationwide population-based study to demonstrate a protective association between green space during childhood and schizophrenia risk; suggesting limited green space as a novel environmental risk factor for schizophrenia. This study supports findings from other studies highlighting positive effects of exposure to natural environments for human health. (c) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

Free