Fabrication and characterization of a glucose-sensitive antibacterial chitosan-polyethylene oxide hydrogel

POLYMER

卷:82

Article

Xiao, Yu^1,2  Gong, Tao³  Jiang, Ying¹  Wang, Yapin²  Wen, Zezhang T.²  Zhou, Shaobing³  Bao, Chongyun¹  Xu, Xiaoming² 

[1] Sichuan Univ, West China Sch Stomatol, State Key Lab Oral Dis, 14,3rd Sect Ren Min Nan Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Louisiana State Univ, Sch Dent, Hlth Sci Ctr, Dept Comprehens Dent & Biomat, 1100 Florida Ave, New Orleans, LA 70119 USA

[3] Southwest Jiaotong Univ, Minist Educ, Key Lab Adv Technol Mat, Sch Mat Sci & Engn, 111,1st Sect North Second Ring Rd, Chengdu 610031, Sichuan, Peoples R China

关键词: Glucose-sensitive;    Hydrogel;    Chitosan;    Polyethylene oxide;    Controlled drug release;    Periodontitis;   

DOI  :  10.1016/j.polymer.2015.11.016

来源: Elsevier

【 摘 要 】

A novel glucose-sensitive chitosanepolyethylene oxide (CS/PEO = 1:0.5-1:2.5) hydrogel with controlled release of metronidazole (MNZ) was obtained by chemical cross-linking and immobilization of glucose oxidase (GO(x)). The hydrogel was characterized by Fourier-transformed infrared spectroscopy (FTIR), compressive mechanical test, rheological analysis, cytotoxicity test, and antibacterial test against Porphyromonas gingivalis. The study found that the CS-PEO composite hydrogel possessed significantly better mechanical properties and biocompatibility than a single-component hydrogel. This might result from the physical cross-linking and formation of semi-interpenetrating network (semi-IPN). In addition, this novel hydrogel has a self-regulating ability to release MNZ in response to the environmental glucose stimulus. Specifically, it released more drugs at higher glucose concentration, thus can lead to a greater ability to inhibit P. gingivalis. This study has demonstrated the glucose-sensitive antibacterial hydrogel has a great potential as a new therapeutic material for treatment or prevention of periodontitis in diabetic patients. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free