Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers

POLYMER

卷:49

Review

Thompson, M. S.^1,2  Vadala, T. P.^1,2  Vadala, M. L.^1,2  Lin, Y.^1,2  Riffle, J. S.^1,2 

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Virginia Polytech Inst & State Univ, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA

关键词: poly(ethylene oxide);    PEO;    polyethylene glycol;    PEG;    polyether;   

DOI  :  10.1016/j.polymer.2007.10.029

来源: Elsevier

【 摘 要 】

Poly(ethylene oxide) (PEO) oligoiners are employed extensively in pharmaceutical and biomedical arenas mainly due to their excellent physical and biological properties, including solubility in water and organic solvents, lack of toxicity, and absence of immunogenicity. PEO can be chemically modified and reacted with, or adsorbed onto, other molecules and surfaces. Sophisticated applications for PEO have increased the demand for PEO oligomers, with tailored functionalities, and heterobifunctional PEOs are often needed. This review discusses the synthesis and applications of heterobifunctional PEO oligomers possessing amine, carboxylate, thiol, and maleimide functional groups. (c) 2007 Elsevier Ltd. All rights reserved.

【 授权许可】

Free