期刊论文详细信息
NEUROPHARMACOLOGY 卷:144
Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress
Article
Joffe, Max E.1,2,3  Santiago, Chiaki I.2  Stansley, Branden J.1,2  Maksymetz, James1,2  Gogliotti, Rocco G.1,2  Engers, Julie L.2  Nicoletti, Ferdinando4,5  Lindsley, Craig W.1,2,3,6  Conn, P. Jeffrey1,2,3 
[1] Vanderbilt Univ, Dept Pharmacol, 12475E MRB4, Nashville, TN 37232 USA
[2] Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN USA
[3] Vanderbilt Ctr Addict Res, Nashville, TN 37232 USA
[4] Univ Sapienza Roma, Dept Physiol & Pharmacol, I-00185 Rome, Italy
[5] IRCCS Neuromed, Pozzilli, Italy
[6] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA
关键词: Stress;    Prelimbic prefrontal cortex;    mGlu(3);    mGlu(5);    Synaptic plasticity;    Reversal learning;   
DOI  :  10.1016/j.neuropharm.2018.10.013
来源: Elsevier
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【 摘 要 】

Stress can precipitate or worsen symptoms of many psychiatric illnesses. Dysregulation of the prefrontal cortex (PFC) glutamate system may underlie these disruptions and restoring PFC glutamate signaling has emerged as a promising avenue for the treatment of stress disorders. Recently, we demonstrated that activation of metabotropic glutamate receptor subtype 3 (mGlu(3)) induces a postsynaptic form of long-term depression (LTD) that is dependent on the activity of another subtype, mGlus. Stress exposure disrupted this plasticity, but the underlying signaling mechanisms and involvement in higher-order cognition have not yet been investigated. Acute stress was applied by 20-min restraint and early reversal learning was evaluated in an operant-based food-seeking task. We employed whole-cell patch-clamp recordings of layer 5 prelimbic (PL)-PFC pyramidal cells to examine mGlu(3)-LTD and several mechanistically distinct mGlus-dependent functions. Acute stress impaired both mGlu(3)-LTD and early reversal learning. Interestingly, potentiating mGlus signaling with the mGlus positive allosteric modulator (PAM) VU0409551 rescued stress-induced deficits in both mGlu(3)-LTD and reversal learning. Other aspects of PL-PFC mGlu(5) function were not disrupted following stress; however, signaling downstream of mGlu(5)-Homer interactions, phosphoinositide-3-kinase (PI3K), Akt, and glycogen synthase kinase 3 beta was implicated in these phenomena. These findings demonstrate that acute stress disrupts early reversal learning and PL-PFC-dependent synaptic plasticity and that potentiating mGlus function can restore these impairments. These findings provide a framework through which modulating coordinated mGlu(3)/mGlus signaling may confer benefits for the treatment of stress-related psychiatric disorders.

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