PET studies in nonhuman primate models of cocaine abuse: Translational research related to vulnerability and neuroadaptations

NEUROPHARMACOLOGY

卷:84

Review

Gould, Robert W.¹  Duke, Angela N.²  Nader, Michael A.² 

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Neurosci Drug Discovery, Dept Pharmacol, Nashville, TN 37232 USA

[2] Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA

关键词: Animal models;    Dopamine;    D2-like receptors;    Sex differences;    PET imaging;    Nonhuman primates;   

DOI  :  10.1016/j.neuropharm.2013.02.004

来源: Elsevier

【 摘 要 】

The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been hypothesized to contribute to high rates of relapse and are described in nonhuman primate models. Lastly, the long-term consequences of cocaine on neurobiology are discussed. PET imaging and longitudinal, within-subject behavioral studies in nonhuman primates have provided a strong framework for designing pharmacological and behavioral treatment strategies to aid drug-dependent treatment seekers. Non-invasive PET imaging will allow for individualized treatment strategies. Recent advances in radiochemistry of novel PET ligands and other imaging modalities can further advance our understanding of stimulant use on the brain. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free