A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders

NEUROPHARMACOLOGY

卷:167

Review

Robinson, Stacey L.^1,2  Thiele, Todd E.^1,2 

[1] Univ N Carolina, Dept Psychol & Neurosci, Davie Hall,CB 3270, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA

关键词: Somatostatin;    Substance abuse;    Anxiety;    Depression;    Fear;    Stress;   

DOI  :  10.1016/j.neuropharm.2020.107983

来源: Elsevier

【 摘 要 】

In recent years, neuropeptides which display potent regulatory control of stress-related behaviors have been extensively demonstrated to play a critical role in regulating behaviors associated with substance abuse and affective disorders. Somatostatin (SST) is one neuropeptide known to significantly contribute to emotionality and stress behaviors. However, the role of SST in regulating behavior has received relatively little attention relative to other stress-involved peptides, such as neuropeptide Y or corticotrophin releasing factor. This review characterizes our current understanding of the role of SST and SST-expressing cells in general in modulating several behaviors intrinsically linked to substance abuse and affective disorders, specifically: anxiety and fear; stress and depression; feeding and drinking; and circadian rhythms. We further summarize evidence of a direct role for the SST system, and specifically somatostatin receptors 2 and 4, in substance abuse disorders. This article is part of the special issue on .Neuropeptides'.

【 授权许可】

Free