Amygdala, neuropeptides, and chronic pain-related affective behaviors

NEUROPHARMACOLOGY

卷:170

Review

Neugebauer, Volker^1,2,3  Mazzitelli, Mariacristina¹  Cragg, Bryce⁴  Ji, Guangchen^1,2  Navratilova, Edita⁵  Porreca, Frank⁵ 

[1] Texas Tech Univ, Sch Med, Dept Pharmacol & Neurosci, Hlth Sci Ctr, Lubbock, TX 79430 USA

[2] Texas Tech Univ, Ctr Excellence Translat Neurosci & Therapeut, Hlth Sci Ctr, Lubbock, TX 79430 USA

[3] Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, Lubbock, TX 79430 USA

[4] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[5] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA

关键词: CGPR;    CRF;    Opioids;    Vasopressin;    Oxytocin;    Amygdala;    Pain;   

DOI  :  10.1016/j.neuropharm.2020.108052

来源: Elsevier

【 摘 要 】

Neuropeptides play important modulatory roles throughout the nervous system, functioning as direct effectors or as interacting partners with other neuropeptide and neurotransmitter systems. Limbic brain areas involved in learning, memory and emotions are particularly rich in neuropeptides. This review will focus on the amygdala, a limbic region that plays a key role in emotional-affective behaviors and pain modulation. The amygdala is comprised of different nuclei; the basolateral (BLA) and central (CeA) nuclei and in between, the intercalated cells (ITC), have been linked to pain-related functions. A wide range of neuropeptides are found in the amygdala, particularly in the CeA, but this review will discuss those neuropeptides that have been explored for their role in pain modulation. Calcitonin gene-related peptide (CGRP) is a key peptide in the afferent nociceptive pathway from the parabrachial area and mediates excitatory drive of CeA neurons. CeA neurons containing corticotropin releasing factor (CRF) and/or somatostatin (SOM) are a source of long-range projections and serve major output functions, but CRF also acts locally to excite neurons in the CeA and BLA. Neuropeptide S (NPS) is associated with inhibitory ITC neurons that gate amygdala output. Oxytocin and vasopressin exert opposite (inhibitory and excitatory, respectively) effects on amygdala output. The opioid system of mu, delta and kappa receptors (MOR, DOR, KOR) and their peptide ligands (beta-endorphin, enkephalin, dynorphin) have complex and partially opposing effects on amygdala function. Neuropeptides therefore serve as valuable targets to regulate amygdala function in pain conditions. This article is part of the special issue on Neuropeptides.

【 授权许可】

Free