Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABAA receptor subtypes

NEUROPHARMACOLOGY

卷:62

Review

Smith, Kiersten S.²  Rudolph, Uwe^1,2 

[1] Harvard Univ, Sch Med, McLean Hosp, Lab Genet Neuropharmacol, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

关键词: GABA(A) receptor;    Anxiety;    Depression;    Benzodiazepines;    Development;   

DOI  :  10.1016/j.neuropharm.2011.07.026

来源: Elsevier

【 摘 要 】

GABA(A) receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA(A) receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA(A) receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA(A) receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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