Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder

NEUROPHARMACOLOGY

卷:62

Review

Norman, Sonya B.^1,2  Myers, Ursula S.^2,3  Wilkins, Kendall C.^2,3  Goldsmith, Abigail A.²  Hristova, Veselina⁴  Robinson, Shannon K.^1,2 

[1] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA

[2] VA San Diego Healthcare Syst, San Diego, CA USA

[3] SDSU UCSD Joint Doctoral Program, San Diego, CA USA

[4] Smith Coll, Northampton, MA 01063 USA

关键词: Posttraumatic stress disorder;    PTSD;    Addiction;    Alcohol disorder;    Substance use disorder;    Comorbidity;    Biological mechanisms;    Pharmacotherapy;   

DOI  :  10.1016/j.neuropharm.2011.04.032

来源: Elsevier

【 摘 要 】

Posttraumatic stress disorder (PTSD) and alcohol/substance use disorder (A/SUD) are frequently comorbid. Comorbidity is associated with poorer psychological, functional, and treatment outcomes than either disorder alone. This review outlines biological mechanisms that are potentially involved in the development and maintenance of comorbid PTSD and A/SUD including neurotransmitter and hypothalamic pituitary adrenal dysregulation, structural differences in the brain, and shared genetic risk factors. The literature regarding pharmacological treatments that have been investigated for comorbid PTSD and A/SUD is also reviewed. Empirical data for each proposed mechanism and pharmacological approach is reviewed with the goal of making recommendations for future research. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. Published by Elsevier Ltd.

【 授权许可】

Free