The impact of exposure to addictive drugs on future generations: Physiological and behavioral effects

NEUROPHARMACOLOGY

卷:76

Review

Vassoler, F. M.¹  Byrnes, E. M.¹  Pierce, R. C.² 

[1] Tufts Univ, Cummings Sch Vet Med, Dept Biomed Sci, Grafton, MA 01536 USA

[2] Univ Penn, Pearlman Sch Med, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19128 USA

关键词: Transgenerationa;    Epigenetic;    Drugs of abuse;    Alcohol;    Nicotine;    Marijuana;    Opioids;    Cocaine;   

DOI  :  10.1016/j.neuropharm.2013.06.016

来源: Elsevier

【 摘 要 】

It is clear that both genetic and environmental factors contribute to drug addiction. Recent evidence indicating trans-generational influences of drug abuse highlight potential epigenetic factors as well. Specifically, mounting evidence suggests that parental ingestion of abused drugs influence the physiology and behavior of future generations even in the absence of prenatal exposure. The goal of this review is to describe the trans-generational consequences of preconception exposure to drugs of abuse for five major classes of drugs: alcohol, nicotine, marijuana, opioids, and cocaine. The potential epigenetic mechanisms underlying the transmission of these phenotypes across generations also are detailed. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free