Genetic causes of PD: A pathway to disease modification

NEUROPHARMACOLOGY

卷:170

Review

Toffoli, M.¹  Vieira, S. R. L.¹  Schapira, A. H., V¹ 

[1] UCL, Dept Clin & Movement Neurosci, Queen Sq Inst Neurol, London, England

关键词: Parkinson disease;    Genetics;    LRRK2;    GBA1;    SNCA;    Disease modifying;    Therapy;   

DOI  :  10.1016/j.neuropharm.2020.108022

来源: Elsevier

【 摘 要 】

The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse. Possibly because of this heterogeneity, no effective disease modifying therapy is available. In this paper we give an overview of the genetics of Parkinson disease and explain how this is relevant for the development of new therapies. This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'.

【 授权许可】

Free