Chronic treatment with antipsychotic drugs does not alter G protein alpha or beta subunit levels in rat brain

NEUROPHARMACOLOGY

卷:35

Article

关键词: antipsychotics;    G proteins;    Western immunoblot;    haloperidol;    clozapine;    SCH 23390;   

DOI  :  10.1016/S0028-3908(96)00119-0

来源: Elsevier

【 摘 要 】

Groups of rats received once daily subcutaneous treatments for 22 days with haloperidol (0.5 mg/kg), clozapine (20 mg/kg), SCH 23390 (0.2 mg/kg) or vehicle. Quantitative immunoblots for G(i alpha 1), G(i alpha 2), G(o alpha), G(s alpha) (45 kD), G(beta 35) and G(beta 36) were performed on membranes from the following brain regions: striatum, nucleus accumbens, substantia nigra, ventral tegmental area (VTA), prefrontal cortex and hippocampus (CA1). No significant alterations were found in the levels of any of these G protein subunits, in any brain region in treated vs control rats. (C) 1997 Elsevier Science Ltd.

【 授权许可】

Free