Glutamate transmission in addiction

NEUROPHARMACOLOGY

卷:56

Review

Kalivas, Peter W.¹  LaLumiere, Ryan T.¹  Knackstedt, Lori¹  Shen, Haowei¹ 

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29464 USA

关键词: Glutamate;    Sensitization;    Drug-seeking;    Ventral tegmental area;    Nucleus accumbens;   

DOI  :  10.1016/j.neuropharm.2008.07.011

来源: Elsevier

【 摘 要 】

Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locornotor sensitization and drUg-seeking. While glUtarnate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction. (c) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

Free