Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling

NEUROPHARMACOLOGY

卷:54

Article

Yin, Henry H.¹  Adermark, Louise¹  Lovinger, David A.¹ 

[1] NIAAA, Sect Synpat Pharmacol, Lab Integrat Neurosci, NIH, Bethesda, MD 20892 USA

关键词: neurotensin;    synaptic plasticity;    neuropeptides;    dopamine;    glutamate;    basal ganglia;    striatum;    endocannabinoid;    CB1;   

DOI  :  10.1016/j.neuropharm.2007.06.004

来源: Elsevier

【 摘 要 】

Neurotensin is a peptide that has been suggested to mimic the actions of antipsychotics, but little is known about how it affects synaptic transmission in the striatum, the major input nucleus of the basal ganglia. In this study we measured the effects of neurotensin on EPSCs from medium spiny projection neurons in the sensorimotor striatum, a region implicated in habit formation and control of motor sequences. We found that bath-applied neurotensin reduced glutamate release from presynaptic terminals, and that this effect required retrograde endocannabinoid signaling, as it was prevented by the CB I cannabinoid receptor antagonist AM251. Neurotensin-mediated inhibition of striatal EPSCs was also blocked by antagonists of D2-like dopamine receptors and group I metabotropic glutamate receptors, as well as by intracellular calcium chelation and phospholipase C inhibition. These results suggest that neurotensin can indirectly engage an endocannabinoid-mediated negative feedback signal to control glutamatergic input to the basal ganglia. Published by Elsevier Ltd.

【 授权许可】

Free