Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?

NEUROPHARMACOLOGY

卷:64

Review

Demirtas-Tatlidede, Asli¹  Vahabzadeh-Hagh, Andrew M.²  Pascual-Leone, Alvaro² 

[1] Istanbul Univ, Behav Neurol & Movement Disorders Unit, Dept Neurol, Istanbul Fac Med, Istanbul, Turkey

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Behav Neurol Unit,Dept Neurol,Med Sch, Boston, MA 02215 USA

关键词: Noninvasive brain stimulation;    Repetitive transcranial magnetic stimulation (TMS, rTMS);    Transcranial direct current stimulation (tDCS);    Theta burst stimulation (TBS);    Neuropsychiatry;    Psychology;    Cognition;    Cognitive;    Depression;    Schizophrenia;    Alzheimer's disease;    ADHD;    Autism;   

DOI  :  10.1016/j.neuropharm.2012.06.020

来源: Elsevier

【 摘 要 】

Cognitive impairment is a core symptom of many neuropsychiatric diseases and a key contributor to the patient's quality of life. However, an effective therapeutic strategy has yet to be developed. Noninvasive brain stimulation techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), are promising techniques that are under investigation for a variety of otherwise treatment-resistant neuropsychiatric diseases. Notably, these tools can induce alterations in neural networks subserving cognitive operations and thus may provide a means for cognitive restoration. The purpose of this article is to review the available evidence concerning cognitive enhancing properties of noninvasive brain stimulation in neuropsychiatry. We specifically focus on major depression. Alzheimer's disease, schizophrenia, autism and attention deficit hyperactivity disorder (ADHD), where cognitive dysfunction is a major symptom and some studies have been completed with promising results. We provide a critical assessment of the available research and suggestions to guide future efforts. This article is part of a Special Issue entitled 'Cognitive Enhancers'. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free